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A Simulation Based Comparison of the Traditional Method, Rolling-6 Design and a Frequentist Version of the Continual Reassessment Method with Special Attention to Trial Duration in Pediatric Phase I Oncology Trials
The Traditional Method (TM), also known as the 3+3 up-and-down design, and the Continual Reassessment Method (CRM) are commonly used in Phase I Oncology Trials to identify the maximum tolerated dose (MTD). The Rolling-6 is a relative newcomer which was developed to shorten trial duration by minimizi...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863035/ https://ncbi.nlm.nih.gov/pubmed/20298812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2010.03.006 |
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