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Continual Reassessment Method vs. Traditional Empirically-Based Design: Modifications Motivated by Phase I Trials in Pediatric Oncology by the Pediatric Brain Tumor Consortium
In this article we provide additional support for the use of a model based design in pediatric Phase I trials, and present our modifications to the continual reassessment method (CRM), which were largely motivated by specific challenges we encountered in the context of the Pediatric Brain Tumor Cons...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2976658/ https://ncbi.nlm.nih.gov/pubmed/19384687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543400902800486 |
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