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The Superiority of the Time-to-Event Continual Reassessment Method to the Rolling Six Design in Pediatric Oncology Phase I Trials

BACKGROUND: The Rolling Six Design (RSD) is currently being used by the Children’s Oncology Group (COG) as their standard design for Phase I trials. Because the COG has large multi-center trials with fast accrual, the motivation for adopting the RSD is to hasten accrual and shorten the duration of t...

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Опубликовано в: :Clin Trials
Главные авторы: Zhao, Lili, Lee, Julia, Mody, Rajen, Braun, Thomas M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281887/
https://ncbi.nlm.nih.gov/pubmed/21610004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774511407533
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