An Msh2 Conditional Knockout Mouse for Studying Intestinal Cancer and Testing Anti-cancer Agents

BACKGROUND & AIMS: Mutations in the DNA mismatch repair (MMR) gene MSH2 cause Lynch Syndromes I & II, and sporadic colorectal cancers (CRCs). Msh2(null) mice predominantly develop lymphoma and do not accurately recapitulate the CRC phenotype. METHODS: We generated and examined mice with a co...

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Main Authors: Kucherlapati, Melanie H., Lee, KyeRyoung, Nguyen, Andrew A., Clark, Alan B., Hou, Harry, Rosulek, Andrew, Li, Hua, Yang, Kan, Fan, Kunhua, Lipkin, Martin, Bronson, Roderick T., Jelicks, Linda, Kunkel, Thomas A., Kucherlapati, Raju, Edelmann, Winfried
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862591/
https://ncbi.nlm.nih.gov/pubmed/19931261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.11.009
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