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Priming and extending: an UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate
We describe a mechanistic model of polyubiquitination by the SCF(β(TrCP2)) E3 ubiquitin (Ub) ligase using human IκBα as a substrate. Biochemical reconstitution experiments revealed that the polyubiquitination of IκBα began with the action of the UbcH5 E2 Ub conjugating enzyme, transferring a single...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862584/ https://ncbi.nlm.nih.gov/pubmed/20347421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2010.02.025 |
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