Non-Native Interactions Are Critical for Mechanical Strength in PKD Domains

Experimental observation has led to the commonly held view that native state protein topology is the principle determinant of mechanical strength. However, the PKD domains of polycystin-1 challenge this assumption: they are stronger than predicted from their native structure. Molecular dynamics simu...

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Detaylı Bibliyografya
Asıl Yazarlar: Forman, Julia R., Yew, Zu Thur, Qamar, Seema, Sandford, Richard N., Paci, Emanuele, Clarke, Jane
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862302/
https://ncbi.nlm.nih.gov/pubmed/20004162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.09.013
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