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Self-consistent determination of the transition state for protein folding: Application to a fibronectin type III domain

We present a general approach in which theory and experiments are combined in an iterative manner to provide a detailed description of the transition state ensemble (TSE) for folding. The method is illustrated by applying it to TNfn3, a fibronectin type III domain protein. In the first iteration, a...

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Autori principali: Paci, Emanuele, Clarke, Jane, Steward, Annette, Vendruscolo, Michele, Karplus, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC141005/
https://ncbi.nlm.nih.gov/pubmed/12515856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.232704999
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