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Metal-Assisted Channel Stabilization: Disposition of a Single Histidine on the N-terminus of Alamethicin Yields Channels with Extraordinarily Long Lifetimes

Alamethicin, a member of the peptaibol family of antibiotics, is a typical channel-forming peptide with a helical structure. The self-assembly of the peptide in the membranes yields voltage-dependent channels. In this study, three alamethicin analogs possessing a charged residue (His, Lys, or Glu) o...

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Detalhes bibliográficos
Main Authors: Noshiro, Daisuke, Asami, Koji, Futaki, Shiroh
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862188/
https://ncbi.nlm.nih.gov/pubmed/20441743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.01.028
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