Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage

The mechanisms underlying synovial joint development remain poorly understood. Here we use complete and cell-specific gene inactivation to identify the roles of the redundant chondrogenic transcription factors Sox5 and Sox6 in this process. We show that joint development aborts early in complete mut...

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Detalhes bibliográficos
Main Authors: Dy, Peter, Smits, Patrick, Silvester, Amber, Penzo-Méndez, Alfredo, Dumitriu, Bogdan, Han, Yu, de la Motte, Carol A., Kingsley, David M., Lefebvre, Véronique
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862098/
https://ncbi.nlm.nih.gov/pubmed/20206616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.02.024
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