Bioengineered Factor IX Molecules with Increased Catalytic Activity Improve the Therapeutic Index of Gene Therapy Vectors for Hemophilia B

Although the desire to develop gene therapy for hemophilia B is high, safety remains a concern. Therefore, improving the therapeutic index of gene therapy vectors is an important goal. Thus, we evaluated the use of three bioengineered factor IX (FIX) variants with improved catalytic activity in the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Brunetti-Pierri, Nicola, Grove, Nathan C., Zuo, Yu, Edwards, Rachel, Palmer, Donna, Cerullo, Vincenzo, Teruya, Jun, Ng, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2009
Assuntos:
Scientific Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861950/
https://ncbi.nlm.nih.gov/pubmed/19196177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2008.084
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados