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Direct visualization of the endomitotic cell cycle in living megakaryocytes: Differential patterns in low and high ploidy cells

Endomitosis in megakaryocytes (MKs) involves repeated DNA replication in the absence of cytokinesis and is a crucial part of MK development. However, chromosomal dynamics have never been observed in living MKs. We developed a new transgenic mouse model in which the expression of human histone H2B fu...

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Detalhes bibliográficos
Main Authors: Papadantonakis, Nicholas, Makitalo, Maria, McCrann, Donald J., Liu, Kenian, Nguyen, Hao G., Martin, Greg, Patel-Hett, Sunita, Italiano, Joseph E., Ravid, Katya
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861775/
https://ncbi.nlm.nih.gov/pubmed/18677109
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