Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

Oxidative stress results in apoptosis of neuronal cells, leading to neurodegenerative disorders. However, the underlying molecular mechanism remains to be elucidated. Here we show that hydrogen peroxide (H(2)O(2)), a major oxidant generated when oxidative stress occurs, induced apoptosis of neuronal...

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Hauptverfasser: Chen, Long, Xu, Baoshan, Liu, Lei, Luo, Yan, Yin, Jun, Zhou, Hongyu, Chen, Wenxing, Shen, Tao, Han, Xiuzhen, Huang, Shile
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861733/
https://ncbi.nlm.nih.gov/pubmed/20142804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2010.36
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