Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway

Hypoxic microenvironment supports cancer stem cell survival, causes poor response to anticancer therapy and tumor recurrence. Inhibition of Notch-1 signaling in adenocarcinoma of the lung (ACL) cells causes apoptosis specifically under hypoxia. Here we found that Akt-1 activation is a key mediator o...

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Detalhes bibliográficos
Main Authors: Eliasz, Sandra, Liang, Shuang, Chen, Yuanbin, De Marco, Melissa A., Machek, Ovidiu, Skucha, Sylvia, Miele, Lucio, Bocchetta, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861728/
https://ncbi.nlm.nih.gov/pubmed/20154720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.7
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