Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia

Pancreatic ductal adenocarcinoma (PDAC) is characterized by its hypovascularity, with an extremely poor prognosis because of its highly invasive nature. PDAC proliferates with abundant stromal cells, suggesting that its invasive activity might be controlled by intercellular interactions between canc...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hirakawa, Toshiki, Yashiro, Masakazu, Doi, Yosuke, Kinoshita, Haruhito, Morisaki, Tamami, Fukuoka, Tatsunari, Hasegawa, Tsuyoshi, Kimura, Kenjiro, Amano, Ryosuke, Hirakawa, Kosei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4972430/
https://ncbi.nlm.nih.gov/pubmed/27487118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159912
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