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Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair

Telomeric repeats preserve genome integrity by stabilizing chromosomes, a function that appears to be important for both cancer and aging. In view of this critical role in genomic integrity, the telomere's own integrity should be of paramount importance to the cell. Ultraviolet light (UV), the...

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Detalhes bibliográficos
Main Authors: Rochette, Patrick J., Brash, Douglas E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861706/
https://ncbi.nlm.nih.gov/pubmed/20442874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000926
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