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Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling
Sunlight's UVB radiation triggers cell signaling at multiple sites to induce apoptosis. The integration of these signal entry sites is not understood. Here we show that P53 and E2f1 constitute a UV-inducible apoptosis switch. At low-UV doses, wild-type cells resemble the OFF state of an siP53-t...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040891/ https://ncbi.nlm.nih.gov/pubmed/17586682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701318104 |
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