Endogenous TCR Recombination in TCR Tg Single RAG-Deficient Mice Uncovered by Robust In Vivo T Cell Activation and Selection

Recombination activating gene (RAG)-deficient TCR (T Cell Receptor) Tg (transgenic) mice are routinely used as sources of monoclonal T cells. We found that after the transfer of T cells from a RAG-2-deficient 5CC7 TCR Tg mice into allogeneic hosts we recovered a population of T cells expressing dive...

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Bibliographic Details
Main Authors: Montaudouin, Caroline, Boucontet, Laurent, Mailhé-Lembezat, Marie-Pierre, Mariotti-Ferrandiz, Maria-Encarnita, Louise, Anne, Six, Adrien, Freitas, Antonio A., Garcia, Sylvie
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861594/
https://ncbi.nlm.nih.gov/pubmed/20454452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010238
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