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p66Shc Links α(1)-Adrenergic Receptors to a Reactive Oxygen Species–Dependent AKT-FOXO3A Phosphorylation Pathway in Cardiomyocytes

p66Shc is an adapter protein that is induced by hypertrophic stimuli and has been implicated as a major regulator of reactive oxygen species (ROS) production and cardiovascular oxidative stress responses. This study implicates p66Shc in an α(1)-adrenergtic receptor (α(1)-AR) pathway that requires th...

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Hlavní autoři: Guo, Jianfen, Gertsberg, Zoya, Ozgen, Nazira, Steinberg, Susan F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861587/
https://ncbi.nlm.nih.gov/pubmed/19168439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.186288
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