Forced Expression of Methionine Adenosyltransferase 1A in Human Hepatoma Cells Suppresses in Vivo Tumorigenicity in Mice

Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the principal methyl donor, and is encoded by MAT1A and MAT2A in mammals. Normal liver expresses MAT1A, which is silenced in hepatocellular carcinoma. We have shown that hepatoma cells overexpressing MAT1A grew slo...

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Bibliografiske detaljer
Main Authors: Li, Jiaping, Ramani, Komal, Sun, Zhanfeng, Zee, Chishing, Grant, Edward G., Yang, Heping, Xia, Meng, Oh, Pilsoo, Ko, Kwangsuk, Mato, José M., Lu, Shelly C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2010
Fag:
Regular Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861110/
https://ncbi.nlm.nih.gov/pubmed/20363925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090810
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