HIF1A Overexpression Is Associated with Poor Prognosis in a Cohort of 731 Colorectal Cancers

Tissue hypoxia commonly occurs in tumors. Hypoxia- inducible factor (HIF)-1 and HIF-2, which are essential mediators of cellular response to hypoxia, regulate gene expression for tumor angiogenesis, glucose metabolism, and resistance to oxidative stress. Their key regulatory subunits, HIF1A (HIF-1α)...

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Main Authors: Baba, Yoshifumi, Nosho, Katsuhiko, Shima, Kaori, Irahara, Natsumi, Chan, Andrew T., Meyerhardt, Jeffrey A., Chung, Daniel C., Giovannucci, Edward L., Fuchs, Charles S., Ogino, Shuji
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861094/
https://ncbi.nlm.nih.gov/pubmed/20363910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090972
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