The Tetraspanin CD37 Protects Against Glomerular IgA Deposition and Renal Pathology

The tetraspanin protein CD37 is a leukocyte-specific transmembrane protein that is highly expressed on B cells. CD37-deficient (CD37(−/−)) mice exhibit a 15-fold increased level of immunoglobulin A (IgA) in serum and elevated numbers of IgA(+) plasma cells in lymphoid organs. Here, we report that CD...

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Autores principales: Rops, Angelique L., Figdor, Carl G., van der Schaaf, Alie, Tamboer, Wim P., Bakker, Marinka A., Berden, Jo H., Dijkman, Henry B.P.M., Steenbergen, Eric J., van der Vlag, Johan, van Spriel, Annemiek B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2010
Materias:
Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861084/
https://ncbi.nlm.nih.gov/pubmed/20348240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090770
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