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Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents
The transient receptor potential vanilloid 1 (TRPV1) channel is the principal detector of noxious heat in the peripheral nervous system. TRPV1 is expressed in many nociceptors and is involved in heat-induced hyperalgesia and thermoregulation. The precise mechanism or mechanisms mediating the thermal...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2860941/ https://ncbi.nlm.nih.gov/pubmed/20424317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41678 |
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