Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents

Although many animal studies indicate insulin has cardioprotective effects, clinical studies suggest a link between insulin resistance (hyperinsulinemia) and heart failure (HF). Here we have demonstrated that excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure ov...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Shimizu, Ippei, Minamino, Tohru, Toko, Haruhiro, Okada, Sho, Ikeda, Hiroyuki, Yasuda, Noritaka, Tateno, Kaoru, Moriya, Junji, Yokoyama, Masataka, Nojima, Aika, Koh, Gou Young, Akazawa, Hiroshi, Shiojima, Ichiro, Kahn, C. Ronald, Abel, E. Dale, Komuro, Issei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2010
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860916/
https://ncbi.nlm.nih.gov/pubmed/20407209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40096
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