Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart failure

To identify a novel target for the treatment of heart failure, we examined gene expression in the failing heart. Among the genes analyzed, Alox15 encoding the protein 12/15 lipoxygenase (LOX) was markedly up-regulated in heart failure. To determine whether increased expression of 12/15-LOX causes he...

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Detalhes bibliográficos
Main Authors: Kayama, Yosuke, Minamino, Tohru, Toko, Haruhiro, Sakamoto, Masaya, Shimizu, Ippei, Takahashi, Hidehisa, Okada, Sho, Tateno, Kaoru, Moriya, Junji, Yokoyama, Masataka, Nojima, Aika, Yoshimura, Michihiro, Egashira, Kensuke, Aburatani, Hiroyuki, Komuro, Issei
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715088/
https://ncbi.nlm.nih.gov/pubmed/19546247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082596
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