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Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
The signaling pathway of insulin/insulin-like growth factor-1/phosphatidylinositol-3 kinase/Akt is known to regulate longevity as well as resistance to oxidative stress in the nematode Caenorhabditis elegans. This regulatory process involves the activity of DAF-16, a forkhead transcription factor. A...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1271675/ https://ncbi.nlm.nih.gov/pubmed/14713953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600045 |
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