Altered regulatory T cell homeostasis in patients with CD4(+) lymphopenia following allogeneic hematopoietic stem cell transplantation

CD4(+)CD25(+)Foxp3(+) Tregs have an indispensable role in the maintenance of tolerance after allogeneic HSC transplantation (HSCT). Patients with chronic graft-versus-host disease (GVHD) have fewer circulating Tregs, but the mechanisms that lead to this deficiency of Tregs after HSCT are not known....

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Autors principals: Matsuoka, Ken-ichi, Kim, Haesook T., McDonough, Sean, Bascug, Gregory, Warshauer, Ben, Koreth, John, Cutler, Corey, Ho, Vincent T., Alyea, Edwin P., Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860902/
https://ncbi.nlm.nih.gov/pubmed/20389017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41072
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