Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease

CD4(+)FoxP3(+) regulatory T cells (Tregs) play a central role in the maintenance of immune tolerance after allogeneic hematopoietic stem cell transplantation. We recently reported that daily administration of low-dose IL-2 induces selective expansion of functional Treg and clinical improvement of ch...

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Main Authors: Matsuoka, Ken-ichi, Koreth, John, Kim, Haesook T., Bascug, O. Gregory, McDonough, Sean, Kawano, Yutaka, Murase, Kazuyuki, Cutler, Corey, Ho, Vincent T., Alyea, Edwin P., Armand, Philippe, Blazar, Bruce R., Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686517/
https://ncbi.nlm.nih.gov/pubmed/23552371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005265
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