Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice

In the adult heart, regulation of fatty acid oxidation and mitochondrial genes is controlled by the PPARγ coactivator–1 (PGC-1) family of transcriptional coactivators. However, in response to pathological stressors such as hemodynamic load or ischemia, cardiac myocytes downregulate PGC-1 activity an...

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Bibliographische Detailangaben
Hauptverfasser: Ahuja, Preeti, Zhao, Peng, Angelis, Ekaterini, Ruan, Hongmei, Korge, Paavo, Olson, Aaron, Wang, Yibin, Jin, Eunsook S., Jeffrey, F. Mark, Portman, Michael, MacLellan, W. Robb
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860901/
https://ncbi.nlm.nih.gov/pubmed/20364083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38331
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