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Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice
In the adult heart, regulation of fatty acid oxidation and mitochondrial genes is controlled by the PPARγ coactivator–1 (PGC-1) family of transcriptional coactivators. However, in response to pathological stressors such as hemodynamic load or ischemia, cardiac myocytes downregulate PGC-1 activity an...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Clinical Investigation
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2860901/ https://ncbi.nlm.nih.gov/pubmed/20364083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38331 |
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