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A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration

Hyperphosphorylation of the microtubule associated protein tau is detected in the brains of individuals with a range of neurodegenerative diseases including Alzheimer's disease (AD). An imbalance in phosphorylation and/or dephosphorylation of tau at disease-related sites has been suggested to i...

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Autors principals: Iijima-Ando, Kanae, Zhao, LiJuan, Gatt, Anthony, Shenton, Christopher, Iijima, Koichi
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860892/
https://ncbi.nlm.nih.gov/pubmed/20159774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq068
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