Bioactivities of Simplified Adociaquinone B and Naphthoquinone Derivatives against Cdc25B, MKP-1, and MKP-3 Phosphatases

Some simplified adociaquinone B analogs and a series of 1,4-naphthoquinone derivatives were synthesized and tested against the three enzymes Cdc25B, MKP-1, and MKP-3. Cdc25B and MKP1 in particular are enzymes overexpressed in human cancer cells, and they represent potential molecular targets for nov...

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Bibliographic Details
Main Authors: Cao, Shugeng, Murphy, Brian T., Foster, Caleb, Lazo, John S., Kingston, David G. I.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860877/
https://ncbi.nlm.nih.gov/pubmed/19028102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.10.090
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