Inducing CTLA-4-dependent Immune Regulation by Selective CD28 blockade Promotes Regulatory T cells in Organ Transplantation

Transplantation is the treatment of choice for patients with end-stage organ failure. Its success is limited by side effects of immunosuppressive drugs, such as inhibitors of the calcineurin pathway that prevent rejection by reducing synthesis of interleukin-2 by T cells. Moreover, none of the exist...

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Main Authors: Poirier, Nicolas, Azimzadeh, Agnes M, Zhang, Tianshu, Dilek, Nahzli, Mary, Caroline, Nguyen, Bao, Tillou, Xavier, Wu, Guosheng, Reneaudin, Karine, Hervouet, Jeremy, Martinet, Bernard, Coulon, Flora, Allain-Launay, Emma, Karam, Georges, Soulillou, Jean-Paul, Pierson, Richard N., Blancho, Gilles, Vanhove, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860737/
https://ncbi.nlm.nih.gov/pubmed/20371478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3000116
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