Antagonist properties of monoclonal antibodies targeting human CD28: Role of valency and the heavy-chain constant domain

Antagonist antibodies targeting CD28 have been proposed as an alternative to the use of CD80/86 antagonists to modulate T cell responses in autoimmunity and transplantation. Advantages would be the blockade of CD28-mediated co-stimulatory signals without impeding the co-inhibitory signals dependent...

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Bibliografische gegevens
Hoofdauteurs: Mary, Caroline, Coulon, Flora, Poirier, Nicolas, Dilek, Nahzli, Martinet, Bernard, Blancho, Gilles, Vanhove, Bernard
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Landes Bioscience 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564885/
https://ncbi.nlm.nih.gov/pubmed/23221503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.22697
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