The Cyclooxygenase Site, But Not the Peroxidase Site of Cyclooxygenase-2 Is Required for Neurotoxicity in Hypoxic and Ischemic Injury

Cyclooxygenase-2 activity has been implicated in the pathogenesis of ischemic injury, but the exact mechanisms responsible for its toxicity remain unclear. Infection of primary neurons with an adenovirus expressing wild type cyclooxygenase-2 increased the susceptibility of neurons to hypoxia. Infect...

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Autors principals: Li, Wenjin, Wu, Shasha, Ahmad, Muzamil, Jiang, Jianfei, Liu, Hao, Nagayama, Tetsuya, Rose, Marie E., Tyurin, Vladimir A., Tyurina, Yulia Y., Borisenko, Grigory G., Belikova, Natalia, Chen, Jun, Kagan, Valerian E., Graham, Steven H.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860550/
https://ncbi.nlm.nih.gov/pubmed/20236388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06674.x
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