The Cyclooxygenase Site, But Not the Peroxidase Site of Cyclooxygenase-2 Is Required for Neurotoxicity in Hypoxic and Ischemic Injury

Cyclooxygenase-2 activity has been implicated in the pathogenesis of ischemic injury, but the exact mechanisms responsible for its toxicity remain unclear. Infection of primary neurons with an adenovirus expressing wild type cyclooxygenase-2 increased the susceptibility of neurons to hypoxia. Infect...

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Hlavní autoři: Li, Wenjin, Wu, Shasha, Ahmad, Muzamil, Jiang, Jianfei, Liu, Hao, Nagayama, Tetsuya, Rose, Marie E., Tyurin, Vladimir A., Tyurina, Yulia Y., Borisenko, Grigory G., Belikova, Natalia, Chen, Jun, Kagan, Valerian E., Graham, Steven H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860550/
https://ncbi.nlm.nih.gov/pubmed/20236388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06674.x
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