The Cyclooxygenase Site, But Not the Peroxidase Site of Cyclooxygenase-2 Is Required for Neurotoxicity in Hypoxic and Ischemic Injury

Cyclooxygenase-2 activity has been implicated in the pathogenesis of ischemic injury, but the exact mechanisms responsible for its toxicity remain unclear. Infection of primary neurons with an adenovirus expressing wild type cyclooxygenase-2 increased the susceptibility of neurons to hypoxia. Infect...

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Detalhes bibliográficos
Main Authors: Li, Wenjin, Wu, Shasha, Ahmad, Muzamil, Jiang, Jianfei, Liu, Hao, Nagayama, Tetsuya, Rose, Marie E., Tyurin, Vladimir A., Tyurina, Yulia Y., Borisenko, Grigory G., Belikova, Natalia, Chen, Jun, Kagan, Valerian E., Graham, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860550/
https://ncbi.nlm.nih.gov/pubmed/20236388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06674.x
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