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Close mimicry of lung surfactant protein B by “clicked” dimers of helical, cationic peptoids

A family of peptoid dimers developed to mimic SP-B is presented, where two amphipathic, cationic helices are linked by an achiral octameric chain. SP-B is a vital therapeutic protein in lung surfactant replacement therapy, but its large-scale isolation or chemical synthesis is impractical. Enhanced...

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Autores principales: Dohm, Michelle T., Seurynck-Servoss, Shannon L., Seo, Jiwon, Zuckermann, Ronald N., Barron, Annelise E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860423/
https://ncbi.nlm.nih.gov/pubmed/19777571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21309
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