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Close mimicry of lung surfactant protein B by “clicked” dimers of helical, cationic peptoids
A family of peptoid dimers developed to mimic SP-B is presented, where two amphipathic, cationic helices are linked by an achiral octameric chain. SP-B is a vital therapeutic protein in lung surfactant replacement therapy, but its large-scale isolation or chemical synthesis is impractical. Enhanced...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2860423/ https://ncbi.nlm.nih.gov/pubmed/19777571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.21309 |
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