Effects of the calcium sensitizer OR-1896, a metabolite of levosimendan, on post-infarct heart failure and cardiac remodelling in diabetic Goto–Kakizaki rats

BACKGROUND AND PURPOSE: Levosimendan is a novel, short half-life calcium sensitizer used as pharmacological inotropic support in acute decompensated heart failure. After oral administration, levosimendan is metabolized to OR-1855, which, in rats, is further metabolized into OR-1896. OR-1896 is a lon...

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Main Authors: Louhelainen, Marjut, Merasto, Saara, Finckenberg, Piet, Vahtola, Erik, Kaheinen, Petri, Levijoki, Jouko, Mervaala, Eero
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2010
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Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860214/
https://ncbi.nlm.nih.gov/pubmed/20412071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00680.x
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