An Orally Active Small Molecule TGF-β Receptor I Antagonist Inhibits the Growth of Metastatic Murine Breast Cancer

BACKGROUND: Transforming growth factor β (TGF-β) plays a complex role in breast carcinogenesis. Initially functioning as a tumor suppressor, this cytokine later contributes to the progression of malignant cells by enhancing their invasive and metastatic potential as well as suppressing anti-tumor im...

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Main Authors: Rausch, Matthew P., Hahn, Tobias, Ramanathapuram, Lalitha, Bradley-Dunlop, Deborah, Mahadevan, Daruka, Mercado-Pimentel, Melania E., Runyan, Raymond B., Besselsen, David G., Zhang, Xiamei, Cheung, H.-Kam, Lee, Wen-Cherng, Ling, Leona E., Akporiaye, Emmanuel T.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860108/
https://ncbi.nlm.nih.gov/pubmed/19528470
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