Systemic Blockade of Transforming Growth Factor-β (TGF-β) Signaling Augments the Efficacy of Immunogene Therapy

Locally-produced TGF-β promotes tumor-induced immunosuppression and contributes to resistance to immunotherapy. This paper explores the potential for increased efficacy when combining immunotherapies with TGF-β suppression using the TGF-β type I receptor kinase inhibitor, SM16. Adenovirus expressing...

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Bibliografiske detaljer
Main Authors: Kim, Samuel, Buchlis, George, Fridlender, Zvi G., Sun, Jing, Kapoor, Veena, Cheng, Guanjun, Haas, Andrew, Cheung, Hung Kam, Zhang, Xiamei, Corbley, Michael, Kaiser, Larry R., Ling, Leona, Albelda, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637471/
https://ncbi.nlm.nih.gov/pubmed/19074893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1494
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