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Structural Basis of Dimerization-dependent Ubiquitination by the SCF(Fbx4) Ubiquitin Ligase
The F-box proteins are the substrate recognition subunits of the SCF (Skp1-Cul1-Rbx1-F- box protein) ubiquitin ligase complexes that control the stability of numerous regulators in eukaryotic cells. Here we show that dimerization of the F-box protein Fbx4 is essential for SCF(Fbx4) (the superscript...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Biochemistry and Molecular Biology
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2859552/ https://ncbi.nlm.nih.gov/pubmed/20181953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.111518 |
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