Protein Phosphatase 2A (PP2A) Holoenzymes Regulate Death-associated Protein Kinase (DAPK) in Ceramide-induced Anoikis

The tumor suppressor, death-associated protein kinase (DAPK), is a Ca(2+)/calmodulin-regulated Ser/Thr kinase with an important role in regulating cytoskeletal dynamics. Autophosphorylation within the calmodulin-binding domain at Ser-308 inhibits DAPK catalytic activity. Dephosphorylation of Ser-308...

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Detalhes bibliográficos
Main Authors: Widau, Ryan C., Jin, Yijun, Dixon, Shelley A., Wadzinski, Brian E., Gallagher, Patricia J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859546/
https://ncbi.nlm.nih.gov/pubmed/20220139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.085076
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