Monoubiquitination Promotes Calpain Cleavage of the Protein Phosphatase 2A (PP2A) Regulatory Subunit α4, Altering PP2A Stability and Microtubule-associated Protein Phosphorylation

Multiple neurodegenerative disorders are linked to aberrant phosphorylation of microtubule-associated proteins (MAPs). Protein phosphatase 2A (PP2A) is the major MAP phosphatase; however, little is known about its regulation at microtubules. α4 binds the PP2A catalytic subunit (PP2Ac) and the microt...

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Detalhes bibliográficos
Main Authors: Watkins, Guy R., Wang, Ning, Mazalouskas, Matthew D., Gomez, Rey J., Guthrie, Chris R., Kraemer, Brian C., Schweiger, Susann, Spiller, Benjamin W., Wadzinski, Brian E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397847/
https://ncbi.nlm.nih.gov/pubmed/22613722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.368613
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