Lysosomal Degradation of α-Synuclein in Vivo

Pathologic accumulation of α-synuclein is a feature of human parkinsonism and other neurodegenerative diseases. This accumulation may be counteracted by mechanisms of protein degradation that have been investigated in vitro but remain to be elucidated in animal models. In this study, lysosomal clear...

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Bibliographic Details
Main Authors: Mak, Sally K., McCormack, Alison L., Manning-Boğ, Amy B., Cuervo, Ana Maria, Di Monte, Donato A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859524/
https://ncbi.nlm.nih.gov/pubmed/20200163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.074617
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