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Substance P Antagonist CP-96345 Blocks Lung Vascular Leakage and Inflammation More Effectively than its Stereoisomer CP-96344 in a Mouse Model of Smoke Inhalation and Burn Injury

The recently developed murine model of smoke inhalation and burn (SB) injury was used to study the effect of the substance-P antagonist CP96345. C57BL/6 mice were pretreated with an i.v. dose of a specific NK-1 receptor antagonist, CP9635, or its inactive enantiomer, CP96344, (10 mg/Kg) 1 hr prior t...

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Detalhes bibliográficos
Main Authors: Jacob, Sam, Deyo, Donald J., Cox, Robert A., Jacob, Reuben K, Herndon, David N., Traber, Daniel L., Hawkins, Hal K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859096/
https://ncbi.nlm.nih.gov/pubmed/20201741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/15376511003674657
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