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Mechanisms of toxic smoke inhalation and burn injury: Role of neutral endopeptidase and vascular leakage in mice

The effects of neutral endopeptidase (NEP) in acute inflammation in the lung were studied using a newly developed murine model of smoke and burn (SB) injury. C57BL/6 mice were pretreated with an i.v. dose of a specific NEP antagonist CGS-24592 (10 mg/Kg) 1 h prior to SB injury (n = 5–8/group). Mice...

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Detalhes bibliográficos
Main Authors: Jacob, Sam, Deyo, Donald J., Cox, Robert A., Traber, Daniel L., Herndon, David N., Hawkins, Hal K.
Formato: Artigo
Idioma:Inglês
Publicado em: Informa Healthcare 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736052/
https://ncbi.nlm.nih.gov/pubmed/19727335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15376510902725649
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