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Pharmacokinetics and Brain Uptake of a Genetically Engineered Bi-functional Fusion Antibody Targeting the Mouse Transferrin Receptor
Monoclonal antibodies (MAb) are potential new therapeutics for brain diseases. However, MAb’s do not cross the blood-brain barrier (BBB). The present work describes the genetic engineering of a fusion protein comprised of a therapeutic single chain Fv (ScFv) antibody and a mouse/rat chimeric MAb aga...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2858389/ https://ncbi.nlm.nih.gov/pubmed/19921848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp900235k |
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