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Pharmacokinetics and Brain Uptake of a Genetically Engineered Bi-functional Fusion Antibody Targeting the Mouse Transferrin Receptor

Monoclonal antibodies (MAb) are potential new therapeutics for brain diseases. However, MAb’s do not cross the blood-brain barrier (BBB). The present work describes the genetic engineering of a fusion protein comprised of a therapeutic single chain Fv (ScFv) antibody and a mouse/rat chimeric MAb aga...

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書誌詳細
主要な著者: Boado, Ruben J., Zhou, Qing-Hui, Lu, Jeff Zhiqiang, Hui, Eric Ka-Wai, Pardridge, William M.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858389/
https://ncbi.nlm.nih.gov/pubmed/19921848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp900235k
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