Llwytho...

RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine

S(N)1-type methylating agents generate O(6)-methyl guanine (O(6)-meG), which is a potently mutagenic, toxic, and recombinogenic DNA adduct. Recognition of O(6)-meG:T mismatches by mismatch repair (MMR) causes sister chromatid exchanges, which are representative of homologous recombination (HR) event...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Rajesh, Preeti, Rajesh, Changanamkandath, Wyatt, Michael D., Pittman, Douglas L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858319/
https://ncbi.nlm.nih.gov/pubmed/20133210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.01.009
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