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RAD51D protects against MLH1-dependent cytotoxic responses to O(6)-methylguanine
S(N)1-type methylating agents generate O(6)-methyl guanine (O(6)-meG), which is a potently mutagenic, toxic, and recombinogenic DNA adduct. Recognition of O(6)-meG:T mismatches by mismatch repair (MMR) causes sister chromatid exchanges, which are representative of homologous recombination (HR) event...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2858319/ https://ncbi.nlm.nih.gov/pubmed/20133210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.01.009 |
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