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A Molecular Mechanism for Proton-Dependent Gating in KcsA

Activation gating in KcsA is elicited by changes in intracellular proton concentration. Thompson et al [1] identified a charge cluster around the inner gate that plays a key role in defining proton activation in KcsA. Here, through functional and spectroscopic approaches, we confirmed the role of th...

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Bibliografiske detaljer
Main Authors: Cuello, Luis G., Cortes, D. Marien, Jogini, Vishwanath, Somporpisut, Amornrat, Perozo, Eduardo
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858269/
https://ncbi.nlm.nih.gov/pubmed/20138880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.02.003
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